2 edition of Regulation of the Ras exchange factor Ras-GRF2. found in the catalog.
Regulation of the Ras exchange factor Ras-GRF2.
Carmen Lenore De Hoog
Written in English
|The Physical Object|
|Number of Pages||161|
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Regulation of the Ras Exchange Factor Ras-GRF2 Carmen Lenore de Hoog Doctor of Philosophy, 1 Department of Molecular and Medical Genetics University of Toronto ABSTRACT The Ras GTPases play a pivotal role in cellular proliferation and differentiation and become activated in response to a variety of extracellular sipals, including gowth andAuthor: de Hoog, Carmen Lenore.
Ensembl ENSG n/a UniProt O P RefSeq (mRNA) NM_ NM_ RefSeq (protein) NP_ NP_ Location (UCSC) Chr 5: – Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene. RAS (MIM ) GTPases Aliases: RASGRF2, GRF2, RAS-GRF2, Ras.
Ras-GRF2, and its close relative Ras-GRF1 (also known as Cdc25Mm), which is expressed primarily in neurons, binds calmodulin (CaM) and activates Ras in response to an elevation in intracellular calcium.Analysis of activated GTP-bound Ras in cell lysates expressing Ras-GRF2 indicated that activation of Ras Regulation of the Ras exchange factor Ras-GRF2.
book Ras-GRF2 requires the Cdc25 domain, but can occur in the absence of the DH domain ().Cited by: Ras-GRF2 (GRF2) is a Regulation of the Ras exchange factor Ras-GRF2. book expressed guanine nucleotide exchange factor (GEF) that stimulates the release of bound guanine nucleotide by the low-molecular-weight G protein Ras (6, 10).GRF2 stimulates the conversion of Ras from its GDP-bound state into a GTP-bound activated by: Ras-GRF2 (GRF2) is a widely expressed GEF which catalyzes nucleotide exchange on Ras through its Cdc25 domain (7, 14).
GRF2 is a bifunctional GEF; in addition to having activity on Ras, GRF2 is capable of binding to another small G protein, Rac1, through its Dbl homology (DH) by: Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Available via license: CC BY Content may be subject to copyright.
The Ras guanine-nucleotide exchange factor Ras-GRF/Cdc25(Mn) harbors a complex array of structural motifs that include a Dbl-homology (DH) domain, usually found in proteins that interact. specificity exchange factor for the Ras and Rac GTPases. A recombinant giutathione S-transferase hision protein containing the Cdc25 domain of Ras-GRF2 stimulated net nucleotide exchange on Ras, in vitro.
Regulation of the Ras exchange factor Ras-GRF2. book with this result, Ras-GRF2 was dso able to activate. RasGRP represents the prototype of a new class of guanine nucleotide exchange factors that activate small GTPases.
The guanyl nucleotide-releasing protein (GRP) family members contain catalytic domains related to CDC25, the Ras exchange factor of Saccharomyces cerevisiae. They also contain a motif resembling a pair of calcium-binding EF-hands and a C1 domain similar to the Cited by: R-Ras proteins share 46–67 percent amino acid identity with each other, and 52–55 percent amino Regulation of the Ras exchange factor Ras-GRF2.
book identity with H-Ras (Figure b), primarily in the consensus guanine nucleotide binding motifs and the switch I and II regions of Ras that alter conformation based on the bound guanine nucleotide (GTP or GDP), permitting function as GDP/GTP-regulated molecular switches (Figure a).Author: Gretchen A.
Repasky, Adrienne D. Cox, Ariella B. Hanker, Natalia Mitin, Channing J. Der. Carmen Lenore De Hoog has written: 'Regulation of the Ras exchange factor Ras-GRF2' Asked in Authors, Poets, and Playwrights What has the author Lenore Kletter written. RasGrf1 and RasGrf2 are large proteins composed by multiple modular domains accounting for protein-protein or protein-lipid interactions which are responsible for functional coupling to upstream and downstream signaling and for fine regulation of their intrinsic exchange activity.
GTP-bound R-Ras and H-Ras can also bind to the p catalytic subunit of PI 3-kinase and Rlf, a guanine nucleotide exchange factor for the Ral family of small GTP-binding proteins. Consequently, we examined the role of these effectors in integrin affinity modulation.
Wang, Z. and Moran, M. () Phospholipase C a Phospholipase and Guanine Nucleotide Exchange Factor. Molecular Intervention 2: Chen, X. and Wang, Z.
() Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase. phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R PRKAA1 Ras protein-specific guanine nucleotide-releasing factor 2 GRF2, RAS-GRF2 RASGRP1 RAS guanyl-releasing protein 1 CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1 RASGRP2.
Membrane association of the tumor suppressor, annexin A6 (AnxA6), has been shown to regulate plasma membrane permeability to extracellular Ca2+, inhibit anchorage-independent tumor cell growth and paradoxically, promote tumor cell motility by mechanisms that remains poorly understood.
Here, we identified RasGRF2, a Ca2+-activated Ras-specific guanine nucleotide exchange factor, as a major. However, under calcium treatment, RAS is activated by other factors, the RAS-guanine-nucleotide-releasing factor 1 (RAS-GRF1) and 2 (RAS-GRF2) (Cullen and Lockyer, ).
Because RAS-GRF1 is mainly expressed in the nerve system and RAS-GRF2 is widely expressed in many tissues (Farnsworth et al., ; Fam et al., ), we therefore. "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways".
European journal of biochemistry / FEBS. (2): – The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.
Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science– Ras-specific guanine nucleotide-releasing factor 2 Eukaryotic translation initiation factor 4E-binding protein 1 GRF2, RAS-GRF2 CALDAG-GEFI, CALDAG-GEFII, RASGRP, V, hRasGRP1 RASGRP2 CALDAG-GEFI, CDC25L hSPRY1 hSPRY2 HSPRY3, spry-3 HH The effect of amphetamine and cocaine on Ras-guanine nucleotide releasing factor 1 (Ras-GRF1) and Ras-GRF2 protein expression in the rat striatum in vivo.
Annual Midwest Anesthesiology Residents Conference, St. Louis, MO, AprilRas-guanine nucleotide-releasing factor 2 (Ras-GRF2) is a Ca 2+ /Calmodulin (CaM) sensor mediating GluN2A-containing NMDAR signaling in mature neurons, Author: Luca Franchini, Nicolò Carrano, Monica Di Luca, Fabrizio Gardoni.
Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia. Proceedings of the National Academy of Sciences (50), pp.
(/pnas) Visigalli, al. The role of p19 C-H-Ras protein in metastasis and proliferative pathways. publicité. View Stefania Fasano’s profile on LinkedIn, the world's largest professional community. Stefania has 6 jobs listed on their profile. See the complete profile on LinkedIn and discover Stefania.
Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia. Annals of Clinical and Translational Neurology 2(6), pp. (/acn). Advances in Neuropharmacology Book Series: International Review of Neurobiology, +.
Colotta V, Lenzi O, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Traini C, Pedata F, Morizzo E and Moro S () Pyrido[2,3- e ]-1,2,4-triazolo[4,3- a ]pyrazinone as a New Scaffold To Develop Potent and.
Comments. Transcription. Descargar versión en castellano. Signal Transduction, Second Edition; Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloging in Publication Data A catalogue record for this book is available from the British Library ISBN: For information on all Academic Press.
Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P () Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A – Lee SY, Voronov S, Letinic K, Nairn AC, Di Paolo G, De Camilli P () Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases.
Buday L. and Downward J. () Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell, 73, Buday L., Warne P.H. and Downward J.
() Down-regulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Full text of "USPTO Patents Application " See other formats. A full 63% of solitary mothers experienced a material or medical hardship during their children’s 1st year the most common of which was borrowing money to pay bills (30%) (Teitler et al.
Although actual support receipt demonstrates solitary mothers’ higher level of need and suggests Ras-GRF2 the likelihood that they will call on others.
Cancer. Medicine e. 5 Editors. ROBERT C. BAST JR., M.D. Internist and Professor of Medicine Vice President for Translational Research Harry Carothers Wiess Chair for Cancer Research University of Texas MD Anderson Cancer Center Houston, Texas.
DONALD W. KUFE, M.D. Professor of Medicine Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts.
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Arseneault is a member of the international Advisory Committee for the Tokyo TEEN Cohort. properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11», en Transplantation, vol.
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UNIVERSIDAD DE GRANADA FACULTAD DE MEDICINA DEPARTAMENTO DE MEDICINA LEGAL, TOXICOLOGÍA Y PSIQUIATRÍA INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS JOSÉ MATAIX VERDÚ COMPLEJO HOSPITALARIO DE JAÉN ANÁLISIS DEL PERFIL DE EXPRESIÓN GÉNICA EN RESPUESTA A LA QUIMIOTERAPIA Y SU RELACIÓN CON EL ESTRÉS.
,年，第32卷，第1期 综述 Ras鸟嘌呤释放因子在脑突触可塑性中的作用研究进展* 杜 青 余 涵 冯 珍1 2 1,3 Ras 鸟嘌呤释放因子（Ras-guanine nucleotide releasing 2 脑突触可塑性 factor, RasGRF ）在中枢神经系统具有广泛作用，尤其在神经 从年Bach 提出.